EURE_CART header image
EURE_CART header image

EURE-CART: (EURopean Endeavour for Chimeric Antigen Receptor Therapies)


Cancer is a chronic disease rapidly becoming the most frequent cause of morbidity and mortality in the EU. Though enormously expensive (several billions EUR/year), currently available anti-cancer therapies are highly toxic and often ineffective and are major causes of chronic diseases. 

Adoptive immunotherapy with T cells genetically modified to express a tumour-reactive chimeric antigen receptor (CAR) is an innovative therapeutic concept, promising to eradicate cancer once for all, without causing chronic disabilities. The goal of EURE-CART is to bring EU at the forefront CAR-T cell immunotherapy and extending its applicability to incurable tumours that so far have never been tackled with this approach.

EURE-CART project’s main object is to conduct a multicentre, first-in-man Phase I/IIa clinical trial to demonstrate the safety and the efficacy of CD44v6 CAR-T cell immunotherapy in acute myeloid leukaemia and multiple myeloma.

CD44v6 CAR-T, is part of the CAR-T (Chimeric antigen-receptor-engineered T cells) family: lymphocytes armed with chimeric receptors that have demonstrated high anti-tumour potential, also against tumours, which are particularly aggressive and resistant to traditional therapies. CAR-CD44v6, which has already been successfully tested in appropriate murine models, represents a product candidate with a particularly high therapeutic potential, as it specifically recognises variant 6 (v6) of the antigen CD44 (CD44v6), expressed by many haematological malignancies, including acute myeloid leukaemia and multiple myeloma - as well as by several epithelial tumours, including breast, colon, pancreatic, head-and-neck and lung carcinomas.

Context & Background

EURE-CART participants believe that patient-derived T cells genetically modified to express a tumour-targeting chimeric antigen receptor (CAR) will contribute to shaping the next generation of personalised cancer therapies. It is therefore anticipated that EURE-CART will have a significant impact on the life and wellbeing of cancer patients, their families and health care providers, as well as on the sustainability and excellence of EU health care systems. 


The main expected impact of EURE-CART is to strengthen the leader role of the EU in translational research, to establish CAR T-cell immunotherapy as the ultimate personalised therapy for cancer and to create secure new jobs in the EU through the instalment of an unprecedented alliance between academia, industry and regulatory bodies.
  • To pioneer CAR-T cell immunotherapy in the EU
  • To make a harmonised effort on advanced therapies
  • To foster the implementation of cellular therapies in the EU
  • Promoting personalised cancer therapy for better outcomes and reduced costs
  • Leveraging the role of advanced therapies for chronic diseases
  • Strengthening the academia-biotech partnership to "make it happen"
  • Creating equal opportunities in the European research area

Expected Impact

Scientific impact: breakthrough research in cancer immunotherapy. The development of immunotherapy strategies for the treatment of cancer was elected ‘Breakthrough of the Year’ by the prestigious Science magazine in 2013, underlying its appeal as a radically innovative and rapidly developing translational research field

Technological impact: bringing the EU at the forefront of advanced therapies. It is expected that EURE-CART will have a considerable and beneficial technological impact on EU research.

Opportunities for economical growth and new jobs: personalised cellular therapeutics as medicinal products. Considering the impressive potential of CAR-T cell immunotherapy, the biotech and pharmaceutical industry has already placed significant investments on its further development at the major academic centres in the US. 

About the consortium

The EURE-CART Consortium is composed of 6 academic centres, 3 SMEs from 5 EU countries, clearly representing excellences in their respective fields. EURE-CART will bring together clinical experts in oncology, and pioneers and leaders in the field of cell and gene therapy for conducting a first-in-man Phase I/II clinical trial. To be successful, EURE-CART proposes the early involvement of National regulatory authorities for accelerating the approval of CAR T-cell immunotherapy, as well as the centralisation of its production by the Molmed Spa. Molmed Spa is uniquely endowed in the EU with the knowhow and experience necessary to meet this ambitious objective, as demonstrated by its unparalleled track record. The main expected impact of EURE-CART is the establishment of CAR T-cell therapy as the ultimate personalised therapy, capable of defeating chronic diseases, and to create secure new jobs in the EU through the instalment of an unprecedented alliance between academia, industry and regulatory bodies.

To carry out this project and to reach clinical translation, a consortium of nine partners from five different EU countries has been established, including clinical, scientific and industrial groups clearly representing excellences in their fields: MolMed S.p.A. (Italy), Ospedale San Raffaele (Italy), Universitätsklinikum Würzburg (Germany), Ospedale Pediatrico Bambino Gesù (Italy), Fundacio Privada Institut de Recerca de L' Hospital de la Santa Creu i Sant Pau (Spain), Fakultni Nemocnice S Poliklinikou Ostrava Foundation (Czech Republic), Istituto Superiore di Sanità (Italy), Acromion GMBH (Germany), ARTTIC SAS (France).

Project Office/General Enquires: undefinedEmail us.

Project Coordinator:
Molmed: Dr. Catia Traversari, Research Director, Milan, Italy 

Please visit our website again soon for more information on the EURE-CART project!


EURE-CART has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 733297.

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With the project coming to an end in June 2021, EURE-CART publishes its... Read more